Endocrine Abstracts

Background: Adipose tissue dysfunction, such as adipocyte hypertrophy and secretion of pro-inflammatory cytokines, develops in obese subjects and goes hand in hand with obesity-related complications, especially insulin resistance (IR) and systemic inflammation. The exact mechanisms underlying adipose tissue dysfunction and consequently the obesity-related complications are not yet fully understood.Aim: Investigate the association between systemic IR and ...

Background: Gender-affirming hormone therapy in transgender persons induces secondary characteristics of the experienced gender. However, androgens and estrogens are also thought to be involved in insulin sensitivity and research suggests a dose-dependent risk for developing insulin resistance when administrated in supraphysiological doses.Aims: To assess the influence of gender-affirming hormone therapy on glucose metabolism in transg...

Background and aims: Obesity induced inflammation is a key component in the pathogenesis of insulin resistance (IR). In addition, obesity-related non-alcoholic fatty liver disease (NAFLD) also seems to contribute to IR development. Until now, however, it is unclear which, if any component of NAFLD specifically associates with IR. Therefore, the aim is to assess if individual components of NAFLD contribute to IR in obese patients undergoing gastric bypass surgery (GBS).<p c...